Establishment of virus resistance

Establishment of virus resistance in grapevine by expression of recombinant antibodies (scFv) against viral proteins

A new method of establishing virus resistance in plants is to format recombinant antibody fragments (scFv, single-chain variable fragments) that are able to recognise and inactivate viral proteins. In the context of a project funded by the European Union (FP5: QLK5-CT-2001-01183), scFv antibodies against viral proteins of the most important grapevine-infecting viruses (GFLV, ArMV, GLRaV-2, GLRaV-3) are being developed and the coding sequences are being transferred into the grapevine by means of genetic transformation. ScFv antibodies are directed against the coat protein, the movement protein or the replicase of the relevant viruses. The formation of these antibodies in the grapevine (rootstocks and varieties) is to prevent the replication and/or spreading of the viruses, which can thus lead to resistance of the grapevine against the relevant viruses.

http://www.molbiotech.rwth-aachen.de/Groups/grapevine/

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